Summary

The mRNA-based BNT162b2 vaccine from Pfizer/BioNTech was the first registered COVID-19 vaccine and has been shown to be up to 95% effective in preventing SARS-CoV-2 infections. Little is known about the broad effects of the new class of mRNA vaccines, especially whether they have combined effects on innate and adaptive immune responses. Here we confirmed that BNT162b2 vaccination of healthy individuals induced effective humoral and cellular immunity against several SARS-CoV-2 variants. Interestingly, however, the BNT162b2 vaccine also modulated the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal and bacterial) stimuli. The response of innate immune cells to TLR4 and TLR7/8 ligands was lower after BNT162b2 vaccination, while fungi-induced cytokine responses were stronger. In conclusion, the mRNA BNT162b2 vaccine induces complex functional reprogramming of innate immune responses, which should be considered in the development and use of this new class of vaccines.

The Concern for the Secretive US Bio-Geopolitics

Oct 10, 2019 - Dan Steinbock Founder, Difference Group

excerpt - "...the neoconservative Project for New American Century (PNAC), the ideological force behind the subsequent Bush administration's foreign policy, declared in its manifesto, Rebuilding America's Defenses (2000), that 'advanced forms of biological warfare that can 'target' specific genotypes may transform biological warfare from the realm of terror to a politically useful tool."

Previously, such efforts at biological 'ethnic bombs"had occurred mainly in apartheid-era South Africa and Rhodesia; the PNAC builds on the Israeli 'ethno-bomb'idea to target specific genetic traits among target populations.

By May 2007, Russia banned all exports of human bio samples due to concern for "genetic bio-weapons" targeting the Russian population. Reportedly, some of these institutions, including Harvard Public Health and USAID, have collected biological material in China as well. In October 2018, Russian Defense Ministry claimed the spread of viral diseases from Georgia, including African swine fever since 2007, could be connected to a US lab network in the area, where more than 70 Georgians had died in odd conditions.

The lab network, a branch of the Nunn-Lugar bio-initiative, belongs to the multimillion-dollar Cooperative Biological Engagement Program (CBEP) funded by Pentagon's Cooperative Threat Reduction Agency (DTRA). The CBEP labs are located in 25 countries, including in Eastern Europe (e.g., Georgia and Ukraine), the Middle East, Africa, and Southeast Asia. In several locations, there have been reported outbreaks of tropical diseases, which are not endemic to the area.

Despite high-level Russian calls for a 'comprehensive evaluation"and 'joint inspections,"pleas for multilateral cooperation have been ignored. In its 2020 multimillion-dollar budget, the DTRA characterizes the "bio-security" program in Asia as 'the partner of choice in a region competing against Chinese influence.'

China Focus

  China military labs DNA database
Cold war 2.0 cover story

as China are once again "the bad guys"
who do the 'dirty work' for the agenda...
meanwhile The Bio-genomics global industry
Hand in hand with the respective Military
are growing exponentially:

"...advanced forms of biological warfare that can "target" specific genotypes may transform biological warfare from the realm of terror to a politically useful tool."

Rebuilding Americas defenses - The Project for the New American Century - 2000

quote: "the vaccine makes the dangerous part of the virus in the body" - PETER MCCULLOUGH MD

what dangerous part? if covid is only dangerous to vulnerable people ... IE 0.02 of the population...so the question needs to be asked - what spike protiein is this mrna gene therapy producing - and is it actually a bioweapon?

"As this, in a sense, bioterrorism phase one was rolled out, it was really all about keeping the population in fear and in isolation and preparing them to accept the vaccine, which appears to be phase two of a bioterrorism operation,"

DR, PETER MCCULLOUGH INTERVIEWED BY REINER FUELLMICH, JUNE 11, 2021 and stating that he believes the vaccine is a BIOWEAPON [video]

Dr Peter McCullough MD testifies to Texas Senate HHS

wayback when - many of The US Army Spec Ops group / Rangers etc ...were chipped with Digital angel RFID chips.

The program aims to develop algorithms that use raw data from smartphone sensors to enable continuous and real-time assessment of warfighters' health status, identifying latent or developing conditions and diseases"

Darpa have developed real time bio data collection & analysis

DARPA

MhealthIntelligence

smartphone collection?

GAVI - Bill Gates AGAIN:

now watch this: the following video proports to show A Hacker backdooring into Russian Sputnik MRNA database

He then finds real time tracking database tracking people via whats now in their bodies after the vaccine.

La Quinta Columna made an urgent announcement that they hope will reach as many people as possible, especially those involved in health and legal services, as biostatistician Ricardo Delgado, Dr. José Luis Sevillano and the team of researchers and professors with whom they have been conducting their research have confirmed the presence of graphene oxide nanoparticles in vaccination vials.

In program nº63, the team showed some photos of the analyses carried out, specifically results obtained by optical and transmission electron microscopy observation, reserving the results of other techniques used for future programs. They also announced that the report based on all the techniques performed, which allowed determining the presence of graphene oxide, will be made official by the researchers who performed the analyses very soon.

Orwell City translated the message from La Quinta Columna and subtitled the video.

via Francis Leader

Nanosystems: Molecular Machinery, Manufacturing, and Computation - K. Eric Drexler

Graphene-based sensors used for human health monitoring

Since the desire for real-time human health monitoring as well as seamless human-machine interaction is increasing rapidly, plenty of research efforts have been made to investigate wearable sensors and implantable devices in recent years.

As a novel 2D material, graphene has aroused a boom in the field of sensor research around the world due to its advantages in mechanical, thermal, and electrical properties.

Numerous graphene-based sensors used for human health monitoring have been reported, including wearable sensors, as well as implantable devices, which can realize the real-time measurement of body temperature, heart rate, pulse oxygenation, respiration rate, blood pressure, blood glucose, electrocardiogram signal, electromyogram signal, and electroencephalograph signal, etc.

Herein, as a review of the latest graphene-based sensors for health monitoring, their novel structures, sensing mechanisms, technological innovations, components for sensor systems and potential challenges will be discussed and outlined.

Frontiers

Graphene’s unique properties have engendered high expectations in a host of areas, including for advanced composites and new types of electronic devices. While graphene can come in many forms, its purest form is that of a one-atom-thick layer of graphite. This structure has provided the highest thermal conductivity ever recorded—10 times higher than copper. It also has one of the highest intrinsic electron mobilities of any material (the speed at which electrons can travel through a material), which is approximately 100 times greater than silicon—a tantalizing property for electronic applications.

IEEE.org

Energy harvested from the device owner

You could be the source of power for your next device, if research into TENGs comes to fruition. A TENG - or triboelectric nanogenerator - is a power harvesting technology which captures the electric current generated through contact of two materials.

A research team at Surrey's Advanced Technology Institute and the University of Surrey have given an insight into how this technology might be put into place to power things like wearable devices. While we're some way from seeing it in action, the research should give designers the tools they need to effectively understand and optimise future TENG implementation.

Future Batteries

INBRAIN Neuroelectronics S.L. is a medical device company dedicated to the development and commercialization of graphene-based neural interfaces and intelligent neuromodulation systems.

SOMA type stress relief?

Engineered small graphene oxide (s-GO) sheets were previously shown to reversibly down-regulate glutamatergic synapses in the hippocampus of juvenile rats, disclosing an unexpected translational potential of these nanomaterials to target selective synapses in vivo.

Synapses are anatomical specializations acting in the Central Nervous System (CNS) as functional interfaces among neurons. Dynamic changes in synaptic function, named synaptic plasticity, are crucial to learning and memory. More recently, pathological mechanisms involving dysfunctional synaptic plasticity were implicated in several brain diseases, from dementia to anxiety disorders.

Hyper-excitability of glutamatergic neurons in the lateral nucleus of the amygdala complex (LA) is substantially involved in the storage of aversive memory induced by stressful events enabling post-traumatic stress disorder (PTSD).

Here we translated in PTSD animal model the ability of s-GO, when stereotaxically administered to hamper LA glutamatergic transmission and to prevent the behavioral response featured in long-term aversive memory. We propose that s-GO, by interference with glutamatergic plasticity, impair LA-dependent memory retrieval related to PTSD. Graphene oxide prevents lateral amygdala dysfunctional synaptic plasticity and reverts long lasting anxiety behavior in rats

see also - Wake Up Dopey

“Two days after injecting graphene oxide into a specific region of the mouse’s brain, it behaved like other mice that had never experienced the smell of a cat in their home environment. In other words, graphene oxide inhibited the mouse’s anxiety-related behaviour,” Ballerini explains. She says that two days is roughly the time for memories to form and be consolidated in the mouse’s brain, which corresponds to the time for the symptoms of anxiety to subside.

“Graphene oxide interacts with the part of the brain responsible for the formation of fear-related memories, which cause anxiety. It doesn’t work like a drug, by inhibiting the function of the receptors – instead, it temporarily halts the entire mechanism long enough to disrupt the brain’s fear-related pathology, without damaging them,” continues Ballerini.

Graphene oxide interrupts anxiety-related neuron signals without affecting the neurons, or the surrounding cells. In simple terms, it only ‘turns down’ the communications between specific neurons. In a disease where these communications are over-expressed, like PTSD and anxiety, targeting the synapses with graphene oxide is enough to halt the development of this pathological behaviour. This is a type of precision medicine."

Graphene flagship EU

New graphene optoelectronic mixers boost high speed Telecommunications

"The photomixing technique developed in this work is a high impact technology for broad range of applications, such as generation of millimetre waves for future wireless systems and radars, or for ultra-stable frequency generation in all radio systems. In this high impact technology, graphene plays an important role. Thanks to its ultrafast nature, it enables all range of high frequencies and, thanks to its high electrooptical efficiency, graphene generates high frequency electromagnetic waves with unprecedented conversion efficiency that, with further developments, could state new records in performance.”

Andrea C. Ferrari, Science and Technology Officer of the Graphene Flagship and Chair of its Management Panel, adds: “We are at the verge of the integration of graphene-based optolectronics into commercial devices. This work, spearheaded by the leading EU Graphene Flagship partner company Thales, shows the industry push for the technology. Our ambition is to see future 5G and 6G devices integrating graphene and layered materials technologies, enabling higher efficiency, speed, and lower power consumption.”"

new-graphene-optoelectronic-mixers-boost-high-speed-telecommunications

Suzanne Gildert

is currently a founder and CTO of Sanctuary AI.

Prior to founding Sanctuary, Suzanne founded Kindred, an artificial intelligence and robotics company. She hand built over 30 robots to demonstrate Kindred’s core technology concept of human robot tele-operation for reinforcement learning.

She grew the company to over 50 employees and opened offices in Vancouver, Toronto, and San Mateo. She helped raise over $50M in venture funding for Kindred from top tier investors including Eclipse, Google Ventures, First Round Capital and Data Collective.

Suzanne also worked for D-Wave, a Canadian company pioneering quantum computing technology.

In 2011, Suzanne joined D-Wave’s machine learning group. In this role she invented and coded most of the use cases D-Wave produced in the period 2011-2013, including MAXCAT, the world’s first quantum computer game, and the world’s first control of a robot by a quantum computer. She also worked on the world’s first supervised binary classifier run on a quantum computer. Her work has been published in several scientific peer reviewed journals, including Nature magazine, and she holds five patents.

She led the quantum computing training programs for Lockheed Martin, Google and NASA.

She designed, coded and ran the company’s Developer Portal and the company website. Prior to joining D-Wave, Suzanne worked at the University of Birmingham, UK, where she earned a PhD in Physics and Electronics and subsequently undertook a postdoctoral role. The role focused on cutting edge research with superconducting devices at ultra-low temperatures, giving her a wealth of experience in the design, fabrication and debugging of complex hardware systems. She has worked with hardware at all scales, from microscopic devices up to large, heavy-duty industrial machinery.

Suzanne is also a published digital artist and poet, has worked as a graphic designer, and pioneered a technique for creating art using a quantum computer. She loves painting using acrylic on canvas, mixed media, digital painting, tapestry, and she also creates electronic music (synthesizer / keyboard / piano) inspired by retro video games and the synthwave genre.

BIO

Why would someone who makes robots be an expert in Quantum Computing?

Ray Kurtzweil 2010 reviews his predictions -
He's now in charge of R&D at Google

Nanofactory

Our nanofactory will be constructed from diamondoid components of the same sort that it can itself manufacture. While molecular manufacturing systems made from DNA, other biopolymers, or even biological organisms are possible, such systems would be unable to build products that approach the remarkable strength, stiffness, temperature range, lightness, electrical, optical and other properties that can achieved with diamondoid materials.

and

The killer app for digital fabrication is personal fabrication - things you can't buy at Walmart. What if, instead of sending energy, computation, etc. around the world, we sent the means to create it? As regular objects become computerized and interconnected at a smaller and smaller scale, we're approaching the nano-scale of biological systems. We're on the cusp of a fabrication revolution. - Neil Gershenfeld, Director of the Center for Bits and Atoms at MIT, in his SC07 keynote address on 13 November 2007.

Molecular assembler

Molecular nanotechnology is the physical underpinning for the singularity

Progress on molecular data storage system

Date: February 4, 2020

A team of Brown University researchers has made substantial progress in an effort to create a new type of molecular data storage system.

In a study published in Nature Communications, the team stored a variety of image files -- a Picasso drawing, an image of the Egyptian god Anubis and others -- in arrays of mixtures containing custom-synthesized small molecules. In all, the researchers stored more than 200 kilobytes of data, which they say is the most stored to date using small molecules. That's not a lot of data compared to traditional means of storage, but it is significant progress in terms of small molecule storage, the researchers say.

"I think this is a substantial step forward," said Jacob Rosenstein, an assistant professor in Brown's School of Engineering and an author of the study. "The large numbers of unique small molecules, the amount of data we can store, and the reliability of the data readout shows real promise for scaling this up even further."

As the data universe continues to expand, much work is being done to find new and more compact means of storage. By encoding data in molecules, it may be possible to store the equivalent of terabytes of data in just a few millimeters of space. Most research on molecular storage has focused on long-chain polymers like DNA, which are well known carriers of biological data. But there are potential advantages to using small molecules as opposed to long polymers. Small molecules are potentially easier and cheaper to produce than synthetic DNA, and in theory have an even higher storage capacity.

The Brown research team, supported by a U.S. Defense Advanced Research Projects Agency (DARPA) grant led by chemistry professor Brenda Rubenstein, has been working to find ways of making small-molecule data storage feasible and scalable.

To store data, the team uses small metal plates arrayed with 1,500 tiny spots less than a millimeter in diameter. Each spot contains a mixture of molecules. The presence or absence of different molecules in each mixture indicate the digital data. The number of bits in each mixture can be as large as the library of distinct molecules available for mixing. The data can then be read out using a mass spectrometer, which can identify the molecules present in each well.

In a paper published last year, the Brown team showed that they could store image files in the kilobyte range using some common metabolites, the molecules that organisms use to regulate metabolism. For this new work, the researchers were able to vastly expand the size of their library -- and thereby the sizes of the files they could encode -- by synthesizing their own molecules.

The team made their molecules using Ugi reactions -- a technique often used in the pharmaceutical industry to quickly produce large numbers of different compounds. Ugi reactions combine four broad classes of reagents (an amine, an aldehyde or a ketone, a carboxylic acid, and an isocyanide) into one new molecule. By using different reagents from each class, the researchers could quickly produce a wide array of distinct molecules. For this work, the team used five different amines, five aldehydes, 12 carboxylic acids, and five isocyanides in different combinations to create 1,500 distinct compounds.

"The advantage here is the potential scalability of the library," Rubenstein said. "We use just 27 different components to make a 1,500-molecule library in one day. That means we don't have to go out and find 1,500 unique molecules."

From there, the team used sub-libraries of compounds to encode their images. A 32-compound library was used to store a binary image of the Egyptian god Anubis. A 575-compound library was used to encode a 0.88-megapixel Picasso drawing of a violin.

The large number of molecules available for the chemical libraries also enabled the researchers to explore alternate encoding schemes that made the readout of data more robust. While mass spectrometry is highly precise, it's not perfect. So as with any system used to store or transmit data, this system will need some form of error correction.

"The way we design the libraries and read out the data includes extra information that lets us correct some errors," said Brown graduate student Chris Arcadia, first author of the paper. "That helped us streamline the experimental workflow and still get accuracy rates as high as 99 percent."

There's still more work to be done to bring this idea up to a useful scale, the researchers say. But the ability to create large chemical libraries and use them for encoding ever larger files suggests the approach can indeed be scaled up.

"We're no longer limited by the size of our chemical library, which is really important," Rosenstein said. "That's the biggest step forward here. When we started this project a few years ago, we had some debates about whether something of this scale was even experimentally feasible. So it's really encouraging that we've been able to do this."

Other co-authors on the paper were Eamonn Kennedy, Joseph Geiser, Amanda Dombroski, Kady Oakley, Shui-Ling Chen, Leonard Sprague, Mustafa Ozmen, Jason Sello, Peter M. Weber, Sherief Reda, Christopher Rose and Eunsuk Kim. The work was funded by DARPA (W911NF-18-2-0031) and the National Science Foundation (1941344).

Science Daily

1960 - There's Plenty of Room at the Bottom An Invitation to Enter a New Field of Physics by Richard P. Feynman

From the Mitre Corporation

MATTER AS SOFTWARE

James C. Ellenbogen, Ph.D.The MITRE Corporation

ABSTRACT

In the next century, as the components of computers continue to shrink smaller and smaller,down to the molecular scale, their physical representation will become more and more like that ofpresent-day computer data.

It is explained in some detail how this ongoing process ofminiaturization is likely to lead to a technology in which matter will acquire desirable physical andeconomic properties much like those of software.

It will be possible to "read" and to "write"functioning computer components and logic structures at will; they will be manufactured locally,on demand, in a manner similar to the way we now "download" software onto disk drives.

In addition, microscopic and submicroscopic mutable computer logic structures will be built intomotile microscopic units of matter, putting the macroscopic properties, form, and function ofmatter itself under program control.

Thus, in the next century, the technology developed forbuilding dramatically smaller computational engines will evolve to have even broadertechnological and economic impacts than have been felt during the last half century of the digitalcomputer revolution.

Mitre.Org