Wake up Dopey! 21st century Psycho-Pharmacotherapy

Capt wardrobe Dec 2020

Apparently on Planet earth in the 21st Century - you have to be happy in order to be healthy, and you have to be healthy in order to be productive for the nation, and to ensure the health of the nation.

United Nations NEP calls on all people and all nations to adopt 'HAPPYTALISM' over Capitalism/Socialism on occasion of July 4 US Independence Day 2019 News provided by United Nations New Economic Paradigm Project Jul 04, 2019, 20:28 ET NEW YORK, July 4, 2019 /PRNewswire/ -- Marking the 2019 July 4 US Independence Day in America, and around the world, the United Nations New Economic Paradigm (NEP) Project is calling on all people, and all nations to adopt 'HAPPYTALISM' over capitalism/socialism, to set humanity free once and for all, achieve the UN's 17 global goals by 2030, and ultimately, the UN's 2012 call for a new economic paradigm which achieves the global happiness and well-being of all life on earth by 2050. Today, the citizens and people of the United States of America, and billions around the world, celebrate one of the most important milestones in the history of all of humankind: the unanimous US Declaration Of Independence on July 4th, 1776, of the first states and citizens of America, from a monarchical, abusive, destructive, despotic, and obsolete system of economic, political, and social rule and governance. The US Declaration of Independence, and the founding states and citizens of America, recognized for the first time in history, that certain Natural Laws and "self evident truths" exist that all human beings are created equal, and have natural, inalienable human rights to "life, liberty, and the pursuit of happiness," the right to democracy and governance by the people over rule by king or inheritance, and the right to revolution.

The US Declaration of Independence states further that it is the duty of the people to abolish and replace any system of government that is destructive, abusive, despotic and obsolete, with a totally new system that is most likely "to effect their safety and happiness." It is the spirit of this natural and fundamental right and duty of all human beings to implement a new, more effective, and just system of governance, where necessary and appropriate that on this July 4 US Independence Day, the United Nations New Economic Paradigm is calling on all people, and all nations, to adopt and implement 'HAPPYTALISM' as a new economic genus and human development paradigm, to replace obsolete, old world and and inadequate systems such as capitalism, socialism, communism, mercantilism, feudalism, among others. The United Nations New Economic Paradigm Project and HAPPYTALISM were founded in 2009 in the wake of the 2007-2009 Global Financial Crisis. "The crisis doesn't only make us free to imagine other models, another future, another world. It obliges us to do so," said former French President Nicolas Sarkozy, who convened the first "Happiness Commission" led by Nobel Economists Joseph Stiglitz and Amartya Sen. In 2011 the United Nations New Economic Paradigm Project successfully gained the support of then-UN Secretary General Ban Ki moon, and all 193 UN Member States to adopt UN resolution 66/281 "The International Day of Happiness" in support of UN resolution 65/309 "Happiness: Towards a Holistic Approach to Development" and the principles, values, articles, and spirit of the UN Charter, the Universal Declaration of Human Rights, and the US Declaration of Independence. HAPPYTALISM is supra and pan systemic, solving siloed crises and issues, such as poverty, inequality, the mental health crisis, climate change, discrimination, freedom and slavery, gender inequality, sustainable economic growth, among others. HAPPYTALISM answers the broader need for a bold new economic and human development system and paradigm that addresses systemic and legacy issues, which exist as a result of the tyranny of the status quo and obsolete mindsets and ways of thinking, and envisions a totally new world where all human beings thrive and are free to live happy and fulfilling lives. HAPPYTALISM uniquely goes above and beyond old world and obsolete economic and political systems, such as capitalism and socialism, by proposing and advancing a philosophy that responds directly to the root causes of global crises, and the confluence of perplexing challenges and opportunities facing all of humankind, with new approaches and solutions. "The time has come for the people around the world to pursue their unalienable right to liberty and the pursuit of happiness, and to adopt and implement HAPPYTALISM replacing the ineffective, and obsolete ways of old such as capitalism and socialism," said Jayme Illien, founder and CEO of the UN New Economic Paradigm Project. "There have been only a few occasions in the history of the world when the citizens of a nation and the world have been called upon to turn the page anew toward a more advanced, sustainable and just system of governance and way of life. One occasion of course was when the founding citizens of America declared independence from the British Monarchy in 1776, which is celebrated today in the US and around the world. Another was when my grandfather, and former President of South Africa, Nelson Mandela, initiated and led the revolution and movement that ended Apartheid in South Africa, and gave birth to a new nation, a new political party, and a new era of democratic governance in South Africa, and the African Continent. Today is yet another as we at the United Nations New Economic Paradigm Project, call on all people, and all nations, to look to the future and shift toward a new economic genus and global development paradigm that promotes and advances solutions to the great challenges and opportunities facing all of us," said Ndaba Mandela, co founder of the United Nations New Economic Paradigm Project and author of Going to the Mountain, the first ever book to tell President Nelson Mandela's life through the eyes of his grandson. "The world needs new lenses to approach growth and how humans and societies can thrive. HAPPYTALISM presents a totally new, optimal, and comprehensive economic genus and human development paradigm to promote and advance the human condition, ensuring the achievement of the UN's Global Goals for Development, and the UN's 2012 call for a new economic paradigm that achieves the 'Global Happiness and Wellbeing of all life on earth' by 2050," said Luis Gallardo, Founder of the Gross Global Happiness Executive Education program held at United Nations University for Peace, Founder of the World Happiness Agora & Fest, and former Global CMO at Deloitte, the world's largest professional services and management consulting firm specializing in advising global CEOs and political leaders, and solving some of the most complex business and worldwide challenges. PR release

"In the UK the LSE's Centre for Economic Performance (CEP) took the lead in organising pilots of the University of Pennsylvania's Resilience Programme for all the 11 year olds in secondary schools. This is an 18 hour programme which teaches the children to observe and manage their own thoughts and feelings, and to understand and respond to the thoughts and feelings of others. The largest effects (compared with controls) were on the children who started off in the most depressed 40% of the class. For them their degree of depression was reduced by 0.2 standard deviations, but by three years later the effect had gone." "One encouraging exception is the so-called Good Behaviour Game piloted in Baltimore. Each beginning primary school class is divided into 3 teams and each team is scored according to the number of times a member of the team breaks one of the be-haviour rules. If there are fewer than 5 infringements all members of the team get a re-ward. Children in the treatment and control groups were followed up right up to age 19-21 and those in the treatment group had significantly lower use of drugs, alcohol and tobacco and significantly lower frequency of anti-social personality disorder.There is one obvious feature of this programme: the amount of time when the game was played totalled around 200 hours. Aristotle was right–habit is central to the de-velopment of character and we shall only produce a more mentally healthy school population if we spend more time on it. "

[excerpted] But in the end what happens will depend ultimately on individuals- what they do themselves and what they get their governments to do. That is why a year ago a social movement was launched called Action for Happiness whose members pledge to try to create the most happiness they can in the world around them and the least misery. That is how we should lead our own lives. But we should also expect our policy-makers to adopt policies which have the same effect. Foremost among them is much more attention to mental health Conclusion This objective is unlikely to be achieved unless each country has a separate cabinet minister for "mental health and social care". This could include mental health promotion and treatment from the cradle to the grave. Within the healthcare system it would establishparity of treatment for mental illness and physical illness. It would also cover non-therapeutic services of care for children and old people. And it would pressurise otherministries, like the ministry of education, to make wellbeing a major objective of policy.For social services the lesson is clear. One of its central purposes should be to un-cover the determinants of human wellbeing. Likewise mental health should routinelybe considered as an influence on any other important outcome, be it earnings, crime,or family stability. And every survey should include questions about mental health. If we want to improve the wellbeing of our society, we need a change of tack. Economic growth is not the magic bullet and happiness depends more on the quality of our rela-tionships and our own inner peace. Mental health is vital for both of these. Improvingit could be the most important single step forwards in the 21st Century. LSE

Gross National happiness? The symbiotic relationship between personal well-being and a Gross National Happiness paradigm is a great example of the circular nature of happiness, though I'm pretty sure Donovan didn't have that in mind in the 1960s. I also suspect that Donovan wasn't talking about the interdependence of happiness and sadness, though that connection is also necessary for good emotional health. source

TechnofascistHappyWorld [TM] The app is like having a little personal action coach in your pocket who: Gives you friendly 'nudges' with an action idea each day Sends you inspiring messages to give you a boost Helps you connect & share ideas with like-minded people People are finding it really helpful and inspiring; for example, Jane said: "I love it. The fact I get daily messages prompting me with the day's happiness challenge and reminding me of good things is perfect" The Action for Happiness app is based on the themes and actions from our popular monthly calendars and aims to give users a couple of friendly "nudges" each day - firstly that day's action in the morning and secondly an inspiring message towards the end of the day. The app was developed in partnership with Disciple Media, using their innovative app platform which helps communities to thrive. source

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London School of Economics = Tavistock Those who read THE TAVISTOCK INSTITUTE FOR HUMAN RELATIONS as a first introduction to the New World Order inside a One World Government will be skeptical; but consider that no less a personage than Sir Halford Mackinder did not hide his beliefs about its coming. More than that, he gave notice that it might be a dictatorship. Mackinder had an impressive resume (CV) having been Professor of Geography at the University of London; a director of the London School of Economics from 1903-1908 and a Member of Parliament from 1910-1922. He was also a close associate of Arnold Toynbee one of the leading lights at Wellington House and had correctly predicted a core of startling geopolitical events, many of them actually coming to pass. One such "prophecy" was the founding of two Germany-s, the Social Democratic Republic of Germany and the Federal Republic of Germany. Critics suggested that he got the information from Toynbee; that it was merely the long range planning of the Committee of 300 that Toynbee knew about. RIIA After Wellington House, Toynbee moved to the Royal Institute for International Affairs (RIIA), and then to London University where he held the chair for International History. In his book, America and World Revolution he said: "If we are to avoid mass-suicide, we must have our worldstate quickly and this probably means that we must have it in a non-democratic form to begin with. We will have to start building a world-state now on the best design that is practicable at the moment." Toynbee went on in a forthright manner saying this "world dictatorship" would have to supplant "the local national states which litter the present political map." The new world-state was to be brought about on the basis of mass mind control and propaganda that would make it acceptable. Self-preservation, ambition, pride, hunger, love of family and children, patriotism, imitativeness, the desire to be a leader, love of play -these and other drives are the psychological raw materials which every leader must take into account in his endeavor to win the public to his point of view. To maintain their self-assurance, most people need to feel certain that whatever they believe about anything is true. Maier files

another quote from the same article

Run an entertainment venue? going out of business?

HAVE SOME FUCKING DMT...

PRESCRIBED NORMALITY - A DOPED UP COMPLIANT LAB RAT POPULATION...

This Psycho-Pharmacotherapy aims to go even deeper. Treating depression with DMT? Really?

SSRI's to treat Covid19? Controlling the "cytokine storm"

A commonly used drug called fluvoxamine was recently tested as a treatment for COVID-19 in the United States. The 152 patients enrolled in the trial had been confirmed to have COVID-19 using a PCR test, and had seen symptoms appear within the past seven days. Patients who already required COVID-19 hospitalisation, or who had an underlying lung condition, congestive heart failure or other immune conditions, were excluded. The study looked only at those who at the time had a relatively mild form of the disease. Among these patients, the study found that taking fluvoxamine reduced the incidence of developing a serious COVID-19 condition over a 15-day period. None of the 80 patients treated with fluvoxamine deteriorated, whereas six (8.3%) of the 72 patients given a placebo saw their condition get worse. Their symptoms included shortness of breath, pneumonia and reduced blood oxygen. The second week of COVID-19 infection is when clinical deterioration is normally seen - which suggests fluvoxamine could be a useful tool in stopping mild COVID-19 from getting worse. But what's unusual is that fluvoxamine is a selective serotonin reuptake inhibitor, or SSRI. SSRIs are the first-line medicine of choice for treating depression, not viral infections. Fluvoxamine is also commonly used to treat obsessive compulsive disorder. So why might it work in a respiratory disease? A not so selective SSRI SSRIs work to treat depression by blocking a protein found on brain cells called the serotonin transporter. When the serotonin transporter is blocked, the amount of serotonin floating around in the brain is increased, which is the important first step as a antidepressant mechanism.

Treatment with an SSRI for a few weeks markedly reduces symptoms of depression in about half of patients. These drugs are very safe, with the most common side-effects being sexual dysfunction, constipation, headache, sleep disturbance and tiredness. Despite their name (selective serotonin reuptake inhibitors), some of these drugs are not entirely selective. In fact, fluvoxamine also binds to another brain cell protein called the σ-1 receptor (S1R). Fluvoxamine potently activates this protein, which has various functions, including inhibition of the production of cytokines - small signalling molecules that help direct the actions of immune cells. Cytokines are one of the most important chemical mediators of the immune response. Thus, it is likely that the effect seen with fluvoxamine in COVID-19 patients has nothing to do with serotonin but everything to do with inhibiting the inflammatory response through the S1R. We know from studies in mice that fluvoxamine can decrease a sepsis-induced inflammatory response and the toxicity that comes with it. A patient in a Brazilian hospital with severe COVID-19 In some patients with severe COVID-19 is it the body's overzealous response to the virus that is most damaging. Photocarioca/Shutterstock And it's becoming increasingly clear that the serious complications seen with COVID-19 are primarily down to an out-of-control inflammatory response to the virus, the so-called "cytokine storm". Here, the body's defence mechanism goes into a dangerous state, where the overactive immune system leads to a toxic inflammatory response, which can lead to death. GAVI

The new paradigm; Neutraceuticals

Vaccines will become a thing of the past

you will gain 'immunity' status via

neutraceuticals in your LAB MADE FOOD

"Speculation on who the winners of the nutraceutical venture will be is becoming a popular topic in papers discussing the pharmaceutical industry. Because new medicines are harder to find and more expensive and risky to develop than ever before, many companies, for example, Du Pont, Abbott Laboratories and Warner Lambert, which have produced conventional pharmaceuticals in the past are now merging to survive, or are turning to nutraceuticals. This offers them a chance of a very large market. Datamonitor, a website that follows market trends, estimates the nutraceutical market at $17bn, and Dr Felice himself, speaking at a conference in 1998, put the figure at $250bn in America alone.3 Although these estimates vary widely, the nutraceuticals market is undoubtably very large and growing. As companies increase in size, more jobs may be created for industrial pharmacists, but the real impact of nutraceuticals on pharmacy will be in the community." Pharmaceutical Journal - 8 JUL 2000

Merck

Dozens of firms are developing cultivated chicken, beef and pork, with a view to slashing the impact of industrial livestock production on the climate and nature crises, as well as providing cleaner, drug-free and cruelty-free meat. Currently, about 130 million chickens are slaughtered every day for meat, and 4 million pigs. By weight, 60% of the mammals on earth are livestock, 36% are humans and only 4% are wild. Revealed: UK supermarket and fast food chicken linked to deforestation in Brazil Read more The cells for Eat Just's product are grown in a 1,200-litre bioreactor and then combined with plant-based ingredients. Initial availability would be limited, the company said, and the bites would be sold in a restaurant in Singapore. The product would be significantly more expensive than conventional chicken until production was scaled up, but Eat Just said it would ultimately be cheaper. The Guardian

The lab-grown meat space just got a big boost from Big Pharma, potentially speeding up adoption of the new products as companies work to bring them to market. The earliest any company plans to introduce so-called "clean meat" items is the end of 2018. Germany-based Merck makes cell culture media, so having business interests in the process of producing lab-grown meat is not a stretch. The company could gain Mosa Meat both as a customer and a beneficiary of its cell culture technology, plus the financial stake gives Merck an insider's role in the trendy segment of lab-grown meat. Should this investment in Mosa Meat work out, Merck could make other investments in the rapidly growing lab-grown meat business. Cargill and Tyson have invested in Memphis Meats, a Silicon Valley lab-grown meat and poultry startup, and Tyson Ventures, the venture capital arm of Tyson Foods, recently co-led a $2.2-million investment round for Israel-based Future Meat Technologies. Mosa Meat isn't the only food company with a pharmaceutical firm behind it. Daiya, which makes vegan and soy-free cheese, was purchased last year by Japanese neutraceutical company Otsuka. The deal was seen as providing the plant-based food company with access to expertise and advanced pharmaceutical-grade equipment from its new parent. Despite the potential benefits, though, financial backing from a pharmaceutical company could add to the impression that lab-grown meat is more of a lab experiment than actual food. U.S. consumers don't seem entirely sure about the products, although 40% of participants in an online survey earlier this year said they would be willing to try lab-grown meat in stores or restaurants. As research and development goes on, questions remain about when cost-effective lab-grown products will hit the market and how the government is going to regulate and label them. A recent phone survey by Consumer Reports found that most consumers think lab-grown meat should be labeled differently than conventionally raised meat from slaughtered animals. Farm and ranch groups couldn't agree more and have asked the U.S. Department of Agriculture to keep lab-grown products from using the word "meat" or "beef" on labels unless what's inside the package is derived from slaughtered animals. Producers of lab-grown meat, poultry or fish may have to engage in a coordinated educational campaign to explain what their products are and how they're made. They stress that the process doesn't kill animals and uses much less water and land — and produces far less greenhouse gas emissions — than conventional animal agriculture, so a sustainability factor is on their side. Food Dive Artificial meat and edible packaging: a taste of future food - Paris Innovation Review

Merck moves into Vaccine Pills?

Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the company is discontinuing development of its SARS-CoV-2/COVID-19 vaccine candidates, V590 and V591, and plans to focus its SARS-CoV-2/COVID-19 research strategy and production capabilities on advancing two therapeutic candidates, MK-4482 and MK-7110. This decision follows Merck’s review of findings from Phase 1 clinical studies for the vaccines. In these studies, both V590 and V591 were generally well tolerated, but the immune responses were inferior to those seen following natural infection and those reported for other SARS-CoV-2/COVID-19 vaccines. Merck continues to advance clinical programs and to scale-up manufacturing for two investigational medicines, MK-7110 and MK-4482 (molnupiravir); molnupiravir is being developed in collaboration with Ridgeback Bio.

Merck MK ULTRA

MDMA German chemists originally synthesized MDMA, or ecstasy, for pharmaceutical purposes in 1912. During the Cold War, the CIA experimented with MDMA as a psychological weapon. Ecstasy had become a popular party drug by the late 1980s, and it’s recreational use is often associated with rave culture, dance parties and electronic music festivals. Despite the illicit drug’s legal status, some medical researchers now believe MDMA could have therapeutic benefits, particularly among people with PTSD, depression and other behavioral issues. German chemists discovered 3,4-methylenedioxymethamphetamine, or MDMA, in 1912 while developing other medicines that could stop bleeding. The substance, they discovered, had unique psychoactive properties. The pharmaceutical company Merck patented MDMA in 1914 as a compound that could have pharmaceutical value. It would be several decades before further drug development would take place. During the Cold War both the U.S. Army and the CIA experimented with MDMA and other hallucinogenic drugs as weapons. MK-Ultra, a CIA project started in the 1950s, worked on the application of psychedelics for mind control. The project became notorious for testing psychoactive drugs on unwitting subjects. The CIA experimented with MDMA as part of MK-Ultra, but only tested the drug on non-human subjects. These experiments produced the first known toxicology studies of MDMA. The drug’s code name was EA-1475. History.Com

Timed release programmable nutrients

"People are looking for a different way to eat, something that is sustainable, healthy and ethical, and marine microalgae can fill in the gaps for people seeking primarily a plant-based diet," Professor Wei Zhang said microalgae could be manipulated to become protein dominant and nutrient rich, providing health benefits for the consumer. Professor Wei Zhang said microalgae's composition can be manipulated, so it can be used in many ways.(ABC News: Michael Clements) "We have the ability to change its composition and therefore its fit for different food and nutritional applications," Mr Zhang said. Research engineer Peng Su said their team can even control how it behaves after being eaten. "I can function how long or how fast I want those nutrients to be released in my body according to my need," Mr Su said. Mr Su said coffee, for example, could be encapsulated within micro-algae balls and manipulated to be released slowly. "I can have coffee [in ball-shaped products] and still have the benefits of coffee, but have it slowly released over 24 hours, so I won't get a headache," he said. source = ABC.Au

UN Sustainable Development

Bytes to Sustain Our Bites: Leveraging Digital Agriculture for Sustainable Development Goals (SDGs) Food and agriculture systems across the globe are undergoing fast systemic changes. A few key emerging trends in the agriculture sector are going to significantly influence the achievement of many of the Sustainable Development Goal (SDG) targets. As food and agriculture systems are becoming more knowledge-intensive, digital technologies will play a more prominent role in the future so that farmers can achieve higher total factor productivity (comprising all of the land, labour, capital, and material resources employed in farm production vis-à- visthe total amount of crop and livestock output of farms) with lesser negative impact to the environment. Mobile telephony, hyperconnectivity and 5G, artificial intelligence and machine learning, Internet of Things (IoT), remote sensing, big data analytics and blockchain are just some of the emerging digital technologies that are expected to transform the food and agriculture systems into Agriculture 4.0 (the Fourth Agriculture Revolution). In order to make the best of technology advancement in the agriculture sector, it is important to understand how technologies evolve, function and flourish in the real world, in tandem with other factors such as infrastructure, policies and legislations and human skills, termed as "Digital Pathways" in this paper.Analysing and understanding these digital pathways will help to strategize, prioritize and actualize the benefits of digital technologies so that they can address the challenges faced by the agriculture and food systems, while at the same time help in gaining better insights about the possible consequences of the digitalization of the agriculture sector in order to identify, avoid or mitigate the associated risks and challenges that technologies might bring in. source - Sept - 2020

The inevitable Bill Gates link

America's Biggest Owner Of Farmland Is Now Bill Gates Ariel Shapiro - Jan 14, 2021 Bill Gates, the fourth richest person in the world and a self-described nerd who is known for his early programming skills rather than his love of the outdoors, has been quietly snatching up 242,000 acres of farmland across the U.S. — enough to make him the top private farmland owner in America. After years of reports that he was purchasing agricultural land in places like Florida and Washington, The Land Report revealed that Gates, who has a net worth of nearly $121 billion according to Forbes, has built up a massive farmland portfolio spanning 18 states. His largest holdings are in Louisiana (69,071 acres), Arkansas (47,927 acres) and Nebraska (20,588 acres). Additionally, he has a stake in 25,750 acres of transitional land on the west side of Phoenix, Arizona, which is being developed as a new suburb. According to The Land Report's research, the land is held directly and through third-party entities by Cascade Investments, Gates' personal investment vehicle. Cascade's other investments include food-safety company Ecolab, used-car retailer Vroom and Canadian National Railway. While it may be surprising that a tech billionaire would also be the biggest farmland owner in the country, this is not Gates' only foray into agriculture. In 2008, the Bill and Melinda Gates Foundation announced $306 million in grants to promote high-yield, sustainable agriculture among smallholder farmers in sub-Saharan Africa and South Asia. The foundation has further invested in the development and proliferation of "super crops" resistant to climate change and higher-yield dairy cows. Last year, the organization announced Gates Ag One, a nonprofit to advance those efforts. It is not entirely clear how Gates' farmland is being used, or whether any of the land is being set aside for conservation. (Cascade did not return Forbes' request for comment.) However, there is some indication that the land could be used in a way that aligns with the foundation's values. Cottonwood Ag Management, a subsidiary of Cascade, is a member of Leading Harvest, a nonprofit that promotes sustainable agriculture standards that prioritize protections of crops, soil and water resources. Gates is not the only billionaire on The Land Report's list of top private farmland owners. Wonderful Company cofounders Stewart and Lynda Resnick (net worth: $7.1 billion) ranked number three with 190,000 acres. Their farmland produces the goods for their brands including POM Wonderful, Wonderful Pistachios and Wonderful Halos mandarins. While Gates may be the country's biggest farmland owner, he by no means is the largest individual landowner. In its list of 100 top American landowners, The Land Report gives the top spot to Liberty Media Chair John Malone, who owns 2.2 million acres of ranches and forests. CNN founder Ted Turner ranked number three with 2 million acres of ranch land across eight states. Even Amazon CEO Jeff Bezos is investing in land on a large scale, landing the 25th spot with his ownership of 420,000 acres, mainly in west Texas. Forbes

Yup ...Gates is Backing Timed released Medicine A meeting between Bill Gates and Boston researchers four years ago has led to the development of a multi-dose capsule that, researchers said, could solve one of medicine's more vexing problems: delivering oral drugs over an extended period of time with one dose. [snip] The capsule, once swallowed, expands into a star-shaped form that prevents it from passing into the small intestine, but allows other food to pass. It releases medicine over the course of days, then, after releasing the final dose, breaks apart and passes through the digestive tract without being absorbed. The capsule represents the latest effort to solve a major flaw in drug delivery: Because the human stomach clears its contents multiple times daily, pill takers must dose themselves frequently. source=StatNews

NHS & Nutraceuticals

Due to open in 2018, the Quadram Institute (QI) will integrate research teams from Institute of Food Research (IFR); the University of East Anglia (UEA)'s Faculty of Science; Norwich Medical School; and the Norfolk and Norwich University Hospitals (NNUH) National Health Service (NHS) Foundation Trust gastrointestinal endoscopy facility. There is a strong microbiome focus in the institute's science vision going forward. The initial multimillion-pound investment for the Quadram Institute is being provided by the Biotechnology and Biological Sciences Research Council (BBSRC) together with IFR, NNUH and UEA. Given the wide range of conditions and diseases affected by the functioning of the gut microbiome, the industry is cognisant of the huge potential to be unleashed with fresh understanding of microbiomes and how they function. Interest ranges from food ingredient producers, consumer goods companies, pharmaceutical industry and medical device companies to biotech and technology service providers.Consumer healthcare offers promising growth opportunities for which pharmaceutical companies are starting to compete with consumer good companies for market share. The importance of food forhealth was already underlined in ancient Greece, Hippocrates: "Let food be thy medicine and medicine be thy food." And in many other traditional cultures, the food is seen as a key to better health and a trusted approach against certain conditions. Since the microbiome can play a critical role determining health, disease and wellness, a whole new spectrum of health-enhancing foods and transformative treatments are on the horizon. OECD

The Quadram Institute

The Quadram Institute is at the forefront of food and health research. Our findings will lead to a better understanding of how what we eat affects our health, and how dietary advice can be improved, personalised and extended based on this. Our extensive expertise in microbiological food safety is also targeting both a reduction in existing causes of foodborne illness, and the safe development of novel foods. As part of our mission, we are also looking at strategies to improve health through food innovation - developing future foods based on our science with a verified ability to improve health - in particular age-related chronic diseases including gut inflammatory syndromes, cardiovascular disease, cancer and cognitive decline. We are working with partners in the UK and internationally to exploit advances in crop genomics to develop new varieties with enhanced nutritional qualities. A collaboration with the John Innes Centre is developing new breeds of wheat with higher levels of resistant starch. With our expertise in food science and the QI Clinical Research Facility, we are fully characterising and verifying the health benefits from this wheat, and products derived from it, and developing novel foods targeting obesity-related conditions such as Type II diabetes. Other projects are taking a similar approach focusing on bioactives, including polyphenols and sulphur-containing metabolites, where we have or are developing new varieties enriched in these compounds that are believed to promote health. These products derive from our long term, detailed studies into the fundamental underlying biological mechanisms and processes by which these bioactive compounds alter metabolic processes in the body that ameliorate the effects of age and diet related chronic disease. As well as delivering nutritionally-enhanced future foods, we are also looking at how the structure of food affects its health promoting abilities. The chemical composition and physical structures of foods determine the rate of digestion and passage through the digestive tract, and the absorption of nutrient within the small and large intestine. This in turn determines the release of gut-derived signalling compounds that are important in satiety. We are developing future foods, such as starch based foods that have controlled glucose release profiles, to understand the factors that influence digestive processes and gut-brain signalling. Using our knowledge of food structure, combined with experiments and clinical trials, we are helping in the development of foods to modify the rates of digestion to prolong, moderate glycaemic response, and also optimise the bioavailability of essential micro-nutrients. In response to consumer demand, we have been helping the food industry to develop a wider range of products, for example more "fresh-like" foods, based on a deeper understanding of microbial lifestyles in the food chain. This is also allowing us to extend the shelf-life of chilled food products, reduce salt, sugar and other preservatives, and contribute to better sustainability of the food chain. To reach consumers and be able to contribute to reducing the burden of diet-related disease, we work with commercial partners to develop future foods. These will be based on the best available evidence for health benefits derived from the expertise and facilities at the Quadram Institute. Quadram Institute